The Owusu-Ansah laboratory at the Department of Physiology and Cellular Biophysics in the CUIMC is seeking a highly motivated postdoctoral scientist to study the regulation of mitochondrial complex I (CI) assembly (see Murari et al., 2022, Science Advances and Murari et al., 2023, Cell Reports). The laboratory employs a combination of blue native polyacrylamide gel electrophoresis (BN-PAGE), in-gel oxidative phosphorylation (OXPHOS) activity assays, Western blots, proteomics, RNA-seq and a range of physiology and cell biology assays to dissect the function of CI. To address this question, our studies have been directed at devising a model system in which we can rigorously examine how CI is assembled, examine the roles of its multiple subunits in bioenergetics and physiology, perform genetic screens to identify new regulators of CI assembly, and create and study various rare CI disease models. While these studies are pursued in fruit flies (Drosophila melanogaster), we anticipate confirming our findings in mammalian systems.
Overview of job responsibilities:
Minimum degree requirement is a PhD or equivalent in cell biology, genetics, biochemistry or other life sciences.
A candidate must have the following:
Columbia University is an Equal Opportunity Employer / Disability / Veteran
Pay Transparency Disclosure
The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to departmental budgets, qualifications, experience, education, licenses, specialty, and training. The above hiring range represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting.